COX-2 upregulation in thymomas and thymic carcinomas
نویسندگان
چکیده
منابع مشابه
Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas.
BACKGROUND Insulin-like growth factor-1 receptor (IGF-1R), epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-type 2 (HER2), and c-Met are members of the receptor tyrosine kinases (RTKs). The associations between the RTK status [protein expression and gene copy number (GCN)] and patient characteristics and between the RTK status and prognosis remain undetermined. ...
متن کاملKIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas.
KIT (CD117), a tyrosine kinase receptor, has not been widely studied in epithelial tumours. In a systematic immunohistochemical survey of KIT expression on tissue arrays incorporating 671 cases, it was found that thymic carcinomas frequently express KIT. Twenty-two thymic carcinomas, 110 thymomas, and 16 non-neoplastic thymus glands were retrieved for further analyses. Immunohistochemically, 19...
متن کاملThymomas and Thymic Carcinomas: a Review on Pathology, Presentation, Staging, Treatment, and Novel Systemic Therapies
Although thymomas and thymic carcinomas only represent 0.2–1.5% of all malignancies, they are the most common tumour found in the anterior mediastinum. Recently, the World Health Organization (WHO) classification of thymic epithelial tumours was revised and a new tumour, node, and metastasis (TNM) staging system is currently being developed. Nearly a third of patients with thymoma present with ...
متن کاملComprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas.
PURPOSE Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped together clinically. However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimum treatment of either entity is unknown. EXPERIMENTAL...
متن کاملHuman Cancer Biology Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped together clinically. However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimum treatment of either entity is unknown. Experimental ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2006
ISSN: 0020-7136
DOI: 10.1002/ijc.22078